Графодатский АС - Curriculum Vitae

1974 – диплом Новосибирского государственного университета

1972-1974 – старший лаборант Института цитологии и генетики СО АН СССР (ИЦиГ), Новосибирск

1974-1976 – стажер-исследователь ИЦиГ СО АН СССР, Новосибирск

1976-1983 – младший научный сотрудник ИЦиГ СО АН СССР, Новосибирск

1979 – защита кандидатской диссертации: “Сравнительная цитогенетика куницеобразных (Carnivora, Mustelidae)” по специальности “Генетика” ИЦиГ СО АН СССР, Новосибирск

1983-1989 – старший научный сотрудник ИЦиГ СО АН СССР, Новосибирск

с 1989 – заведующий лабораторией цитогенетики животных ИЦиГ СО АН СССР, Новосибирск

1992 – защита докторской диссертации: “Цитогенетические аспекты филогении млекопитающих” по специальности “Генетика”, ИЦиГ СО АН СССР, Новосибирск

2009-2012 – заведующий лабораторией цитогенетики животных ОМКБ, Институт химической биологии и фундаментальной медицины СО РАН, Новосибирск

с 2012 – заведующий лабораторией цитогенетики животных, заведующий Отделом разнообразия и эволюции геномов Института молекулярной и клеточной биологии СО РАН, Новосибирск

2012-2017 – заместитель директора по научной работе Института молекулярной и клеточной биологии СО РАН, Новосибирск

с 2017 – Руководитель научного направления Института молекулярной и клеточной биологии СО РАН, Новосибирск

• Совет РАН по программе «Геном человека» (1990-1998)
• Объединенный Ученый совет СО РАН по биологическим наукам (1998-2009)
• Звание Профессор генетики (с 2003)
• Научный совет по генетике и селекции РАН (с 2012)
• Член оргкомитета Project Genome 10K (c 2009)
• Член Human Genome Organisation (HUGO) (c 1995)
• Член-корреспондент РАН (с 2019)

• Chromosome Research (Germany)
• BMC Genetics (UK)
• Comparative Cytogenetics (Санкт-Петербург)
• Genes (Switzerland)

• Премия СО АН СССР (биология) (1986)
• Премия имени АА Баева РАН (1995)
• Юбилейная медаль "300 лет Российской академии наук" (2024)

Цитогенетика, разнообразие геномов, эволюция млекопитающих

Автор более 230 научных публикаций, среди которых 4 монографии на русском языке и 4 на английском языке

• Графодатский АС, Исаенко АА, Терновский ДВ, Раджабли СИ. Конститутивный гетерохроматин и размеры геномов ряда видов куницеобразных (Carnivora, Mustelidae). Генетика 13: 2123-2128, 1977
• Графодатский АС, Раджабли СИ. Хромосомы сельскохозяйственных и лабораторных животных. Атлас. Новосибирск. Наука. 1988
• Graphodatsky AS. Conserved and variable elements of mammalian chromosomes. in: Halnan CRE, ed. Cytogenetics of animals, Oxon, UK: CAB International Press, 1989, pp 95-124
• Vorobieva N, Protopopov A, Protopopova M, Modi B, Alikmets R, Kashuba V, Zabarovsky E, Kisselev L, Klein G, Graphodatsky A. Localization of human arf2 and nck genes and 13 other Not1 linking clones to chromosome 3 by fluorescence in situ hybridization. Cytogenet Cell Genet 68: 91-94, 1995
• Yang F., O'Brien PCM, Milne BS, Graphodatsky AS, Solanky N, Trifonov V, Rens W, Sargan D, Ferguson-Smith MA. A complete comparative chromosome map for the dog, red fox and human and its integration with canine genetic maps. Genomics 62: 189-202, 1999
• Graphodatsky AS, Yang F, O’Brien PCM, Perelman P, Milne N, Serdukova N, Kawada S-I, Ferguson-Smith MA. Phylogenetic implications of the 38 putative ancestral chromosome segments for four canid species. Cytogenet Cell Genet 92: 243-247, 2001
• Graphodatsky AS, Yang F, Perelman PL, O'Brien PCM, Serdukova NA, Milne BS, Biltueva LS, Fu B, Vorobieva NV, Kawada S-I, Robinson TJ, Ferguson-Smith MA. Comparative molecular cytogenetic studies in the order Carnivora: mapping chromosomal rearrangements onto the phylogenetic tree. Cytogenet Genome Res 96: 137-145, 2002
• Yang F, Alkalaeva EZ, Perelman PL, Pardini AT, Harrison WR, O’Brien PCM, Fu B, Graphodatsky AS, Ferguson-Smith MA. Reciprocal chromosome painting between human, aardvark and elephant (Superorder Afrotheria) reveals the likely eutherian ancestral karyotype. Proc Natl Acad Sci USA 100: 1062-1066, 2003
• Yang F. Graphodatsky A.S. Integrated comparative genome maps and their implications for karyotype evolution of carnivores. in: Chromosome today, Schmid M and Nanda I, eds. Kluwer Academic Publishers, The Netherlands 14: 215-224, 2004
• Graphodatsky AS, Kukekova AV, Yudkin DV, Trifonov VA, Vorobieva NV, Beklemisheva VR, Perelman PL, Graphodatskaya DA, Trut LN, Yang F., Ferguson-Smith MA, Acland GM, Aguirre GD. The proto-oncogene c-kit maps to canid B-chromosomes. Chromosome Res 13: 113-122, 2005
• Graphodatsky A. Contributed karyotypes. in: Atlas of Mammalian Chromosomes, O’Brien SJ, Nash WG, Menninger JC, ed’s. John Wiley and Sons Publishers, 2006, 15, 44, 52, 177-180; 182-183; 187; 188; 200-216; 218; 220-221; 237-239; 241-252; 255-262; 264-268; 275; 277-278; 279; 281-283; 286-287; 310; 314-319; 322; 324, 341; 346; 360; 362-365; 366-369; 372-373; 374; 375-376; 377; 367-368; 462; 484-493; 494; 496; 497; 500; 509; 566; 574; 587; 591-592; 606; 610; 611; 649-650; 671; 652-653
• Yang F, Graphodatsky AS, Li T, Fu B, Dobigny G, Wang J, Perelman PL, Serdukova NA, Su W, O’Brien PCM, Wang Y, Ferguson-Smith MA, Volobouev V, Nie W. Comparative genome maps of the pangolin, hedgehog, sloth, anteater and human revealed by cross-species chromosome painting: further insight into the ancestral karyotype and genome evolution of eutherian mammals. Chromosome Res 14: 283-296, 2006
• Romanenko SA, Perelman PL, Serdukova NA, Trifonov VA, Biltueva LS, Wang J, Li T, Nie W, O’Brien PCM, Volobouev VT, Stanyon R, Ferguson-Smith MA, Yang F, Graphodatsky AS. Reciprocal chromosome painting between three laboratory rodent species. Mammalian Genome 17: 1183-1192, 2006
• Lutz F, Graphodatsky A, Muller S, Lyons LA, Robinson TJ, Volleth M, Yang F, Wienberg J. Are molecular cytogenetics and bioinformatics suggesting diverging models of ancestral mammalian genomes? Genome Res 16: 306-310, 2006
• Графодатский АС. Сравнительная хромосомика. Мол Биол 41: 408-422, 2007
• Romanenko SA, Volobouev VT, Perelman PL, Lebedev VS, Serdukova NA, Trifonov VA, Biltueva LS, Nie W, O’Brien PCM, Bulatova NS, Ferguson-Smith MA, Yang F, Graphodatsky AS. Karyotype evolution and phylogenetic relationships of hamsters (Cricetidae, Muroidea, Rodentia) inferred from chromosomal painting and banding comparison. Chromosome Res 15: 283-297, 2007
• Graphodatsky AS, Perelman PL, Sokolovskaya NV, Beklemisheva VR, Serdukova NA, O’Brien SJ, Ferguson-Smith MA, Yang F. Phylogenomics of the dog and fox family (Canidae, Carnivora) revealed by chromosome painting. Chromosome Res 16: 129-143, 2008
• Graphodatsky AS, Yang F, Dobigny G, Romanenko SA, Biltueva LS, Perelman PL, Beklemisheva VR, Alkalaeva EZ, Serdukova NA, Ferguson-Smith MA, Murphy WJ, Robinson TJ. Tracking genome organization in rodents by ZOO-FISH. Chromosome Res 16: 261-274, 2008
• Yang F, Graphodatsky AS. Animal probes and ZOO-FISH fluorescence in situ hybridization (FISH). in: Application guide, Liehr T, ed., Springer, 2009, 323-347
• Kulemzina AI, Trifonov VA, Perelman PL, Rubtsova NV, Volobuev V, Ferguson-Smith MA, Stanyon R, Yang F, Graphodatsky AS. Cross-species chromosome painting in Cetartiodactyla: reconstructing the karyotype evolution in key phylogenetic lineages. Chromosome Res 17: 419-436, 2009
• Genome 10K community of scientists. A proposal to obtain whole genome sequence for 10,000 vertebrate species. J Heredity 100: 659-674, 2009
• Beklemisheva VR, Romanenko SA, Biltueva LS, Trifonov VA, Vorobieva NV, Serdukova NA, Rubtsova NV, Brandler OV, O'Brien PC, Yang F, Stanyon R, Ferguson-Smith MA, Graphodatsky AS. Reconstruction of karyotype evolution in core Glires. I. The genome homology revealed by comparative chromosome painting. Chromosome Res 19: 549–565, 2011
• Vorobieva NV, Sherbakov DY, Druzhkova AS., Stanyon R, Tsybankov AA, Vasiljev SK, Shunkov MV, Trifonov VA, Graphodatsky AS. Genotyping of Capreolus pygargus fossil DNA from Denisova Cave reveals phylogenetic relationships between ancient and modern populations. PLoS One 6(8): e24045, 2011
• Graphodatsky AS, Trifonov VA, Stanyon R. The genome diversity and karyotype evolution of mammals. Mol Cytogen 4: 22, 2011
• Romanenko SA, Perelman PL, Trifonov VA, Graphodatsky AS. Chromosomal evolution of Rodentia. Heredity 108: 4-16, 2011
• Stanyon R, Graphodatsky A. (Ed’s) Evolutionary dynamics of mammalian karyotypes. Karger, Basel, Switzerland, 2012, 208 pp
• Nie W, Wang J, Su W, Wang D, Tanomtong A, Perelman PL, Graphodatsky AS, Yang F. Chromosomal rearrangements and karyotype evolution in carnivores revealed by chromosome painting. Heredity 108: 17-27, 2012
• Romanenko SA, Perelman PL, Trifonov VA, Graphodatsky AS. Chromosomal evolution of Rodentia. Heredity 108: 4-16, 2012
• Thalmann O,... , Druzhkova A, Graphodatsky A,... Wayne RK. Complete mitochondrial genomes of ancient canines suggest a European origin of domestic dogs. Science 342: 871-874, 2013
• Kulemzina AI, Perelman PL, Grafodatskaya DA, Nguyen TT, Thompson M, Roelke-Parker ME, Graphodatsky AS. Comparative chromosome painting of pronghorn (Antilocapra americana) and saola (Pseudoryx nghetinhensis) karyotypes with human and dromedary camel probes. BMC Genetics 15: 68, 2014
• Romanenko SA, Biltueva LS, Serdyukova NA, Kulemzina AI, Beklemisheva VR, Gladkikh OL, Lemskaya NA, Interesova EA, Korentovich MA, Vorobieva NV, Graphodatsky AS, Trifonov VA. Segmental paleotetraploidy revealed in sterlet (Acipenser ruthenus) genome by chromosome painting. Mol Cytogenet 8: 90, 2015
• Romanenko SA, Perelman PP, Trifonov VA, Serdyukova NA, Li T, Fu B, O’Brien PCM, Ng BL, Nie W, Liehr T, Stanyon R, Graphodatsky AS, Yang F. A first generation comparative chromosome map between guinea pig (Cavia porcellus) and humans. PLoS ONE 10(5): e0127937, 2015
• Trifonov VA, Romanenko SS, Beklemisheva VR, Biltueva LS, Makunin AI, Lemskaya NA, Kulemzina AI, Stanyon R, Graphodatsky AS. Evolutionary plasticity of acipenseriform genomes. Chromosoma 125: 661-668, 2016
• Beklemisheva VR, Perelman PL, Lemskaya NA, Kulemzina AI, Proskuryakova AA, Burkanov VN, Graphodatsky AS. The ancestral carnivore karyotype as substantiated by comparative chromosome painting of three pinnipeds, the walrus, the steller sea lion and the Baikal seal (Pinnipedia, Carnivora). PLoS ONE 11(1): e0147647, 2016
• Druzhkova AS, Makunin AI, Vorobieva NV, Vasiliev SK, Ovodov ND, Shunkov MV, Trifonov VA, Graphodatsky AS. Complete mitochondrial genome of an extinct Equus (Sussemionus) ovodovi specimen from Denisova cave (Altai, Russia). Mitochondrial DNA Part B 2(1): 79-81, 2017
• Proskuryakova AA, Kulemzina AI, Perelman PL, Makunin AI, Larkin DM, Farré M, Kukekova AV, Johnson JL, Lemskaya NA, Beklemisheva VR, Roelke-Parker ME, Bellizzi J, Ryder OA, O’Brien SJ, Graphodatsky AS. X chromosome evolution in Cetartiodactyla. Genes 8(9): 216, 2017
• Romanenko SA, Serdyukova NA, Perelman PL, Pavlova SV, Bulatova NS, Golenishchev FN, Stanyon R, Graphodatsky AS. Intrachromosomal rearrangements in rodents from the perspective of comparative region-specific painting. Genes 8(9): 215, 2017
• Biltueva LS, Prokopov DY, Makunin AI, Komissarov AS, Kudryavtseva AV, Lemskaya NA, Vorobieva NV, Serdyukova NA, Romanenko SA, Gladkikh OL, Graphodatsky AS, Trifonov VA. Genomic organization and physical mapping of tandemly arranged repetitive DNAs in sterlet (Acipenser ruthenus). Cytogenet Genome Res 152: 148-157, 2017
• Andreyushkova DA, Makunin AI, Beklemisheva VR, Romanenko SA, Druzhkova AS, Biltueva LB, Serdyukova NA, Graphodatsky AS, Trifonov VA. Next generation sequencing of chromosome-specific libraries sheds light on genome evolution in paleotetraploid sterlet (Acipenser ruthenus). Genes 8(11): 318, 2017
• Teeling EC, Vernes SC, Dávalos LM, Ray DA, Gilbert MTP, Myers E, Bat1K Consortium [includes Graphodatsky AS]. Bat biology, genomes, and the Bat1K Project: to generate chromosome-level genomes for all living bat species. Annu Rev Anim Biosci 6: 23-46, 2018
• Proskuryakova AA, Kulemzina AI, Perelman PL, Serdukova NA, Ryder OA, Graphodatsky AS. The case of X and Y localization of nucleolus organizer regions (NORs) in Tragulus javanicus (Cetartiodactyla, Mammalia). Genes 9(6): 312, 2018
• Makunin AI, Rajičić M, Karamysheva TV, Romanenko SA, Druzhkova AS, Blagojević J, Vujošević M, Rubtsov NB, Graphodatsky AS, Trifonov VA. Low-pass single-chromosome sequencing of human small supernumerary marker chromosomes (sSMCs) and Apodemus B chromosomes. Chromosoma 127(3): 301–311, 2018
• Makunin AI, Romanenko SA, Beklemisheva VR, Perelman PL, Druzhkova AS, Petrova KO, Prokopov DY, Chernyaeva EN, Johnson JL, Kukekova AV, Yang F, Ferguson-Smith MA, Graphodatsky AS, Trifonov VA. Sequencing of supernumerary chromosomes of red fox and raccoon dog confirms a non-random gene acquisition by B chromosomes. Genes 9(8): 405, 2018
• Kukekova AV,... Serdyukova NA,... Beklemischeva V,... Perelman PL, Graphodatsky AS,... Zhang G. Red fox genome assembly identifies genomic regions associated with tame and aggressive behaviours. Nature Ecol Evol 2: 1479-1491, 2018 
• Farré M, Kim J, Proskuryakova AA, Zhang Y, Kulemzina AI, Li Q, Zhou Y, Xiong Y, Johnson JL, Perelman P, Johnson WE, Warren WC, Kukekova AV, Zhang G, O'Brien SJ, Ryder OA, Graphodatsky AS, Ma J, Lewin HA, Larkin DM. Evolution of gene regulation in ruminants differs between evolutionary breakpoint regions and homologous synteny blocks. Genome Res 29(4): 576-589, 2019
• Farré M, Li Q, Darolti I, Zhou Y, Damas J, Proskuryakova AA, Kulemzina AI, Chemnick LG, Kim J, Ryder OA, Ma J, Graphodatsky AS, Zhang G, Larkin DM, Lewin HA. An integrated chromosome-scale genome assembly of the Masai giraffe (Giraffa camelopardalis tippelskirchi). GigaScience 8(8): giz090, 2019
• Atlas of mammalian chromosomes (2nd edition). eds. Graphodatsky AS, Perelman PL, O’Brien SJ. Wiley-Blackwell, USA, 2020, 1008 p
• Librado P, ... Kusliy MA, ... Graphodatsky AS, ... Orlando L. The origins and spread of domestic horses from the Western Eurasian steppes. Nature 598: 634-640, 2021
• Romanenko SA, Lebedev VS, Bannikova AA, Pavlova SV, Serdyukova NA, Feoktistova NYu, Jiapeng Q, Yuehua S, Surov AV, Graphodatsky AS. Karyotypic and molecular evidence supports the endemic Tibetan hamsters as a separate divergent lineage of Cricetinae. Sci Rep 11: 10557, 2021