Laboratory of Human Disease Models

Kozhevnikova Elena
Head of the Laboratory

Staff: 
thomson_logo.gif scopus_logo.jpg Kozhevnikova Elena head PhD (Biology) kozhevnikovaatmcb [dot] nsc [dot] ru
thomson_logo.gif scopus_logo.jpg Popova Julia research fellow PhD (Biology) popovaatmcb [dot] nsc [dot] ru
      Zybkina Anastassia research fellow PhD (Biology)  
thomson_logo.gif scopus_logo.jpg   Medvedeva (Sajdakova) Snezhanna junior research fellow   medvedevaatmcb [dot] nsc [dot] ru
      Andrejeva Jelizaveta research assistant   andreeva [dot] eatmcb [dot] nsc [dot] ru
      Nikelvart Ekaterina research assistant   nikelvartatmcb [dot] nsc [dot] ru
      Kulygina Yulia part-time research fellow PhD (Medicine)  
      Saeidi Arsalan part-time junior research fellow   saeidiatmcb [dot] nsc [dot] ru

Former research workers:

Achasova Kseniya, PhD
Chanushkina Kseniya
Morozova Maryana, PhD
Struchalin Maksim, PhD
Vikhorev Alexander
Zedan Yazan

Research: 

The Laboratory of Human Disease Models focuses on studying the molecular and genetic mechanisms of inflammatory bowel diseases (IBD) and associated disorders. We utilize laboratory animals and 3D colonic organoids to recapitulate IBD in the lab. By combining these models with confocal microscopy, “-omic” approaches, and functional tests, we investigate the molecular mechanisms of epithelial barrier disruption in IBD. Additionally, the laboratory explores the role of the gut microbiota and its metabolism as regulators of psychiatric disorders associated with IBD, such as depression and anxiety.

Recent publications: 

  1. Medvedeva S, Achasova K, Boldyreva L, Ogienko A, Kozhevnikova E. The application of explants, crypts, and organoids as models in intestinal barrier research. Tissue Barriers, 2024, doi: 10.1080/21688370.2024.2423137

  2. van der Meer JW, ... Kozhevnikova EN, ... Verrijzer CP. Hao-Fountain syndrome protein USP7 controls neuronal differentiation via BCOR-ncPRC1.1. (doi: 10.1101/gad.352272.124) Genes Dev 39(5-6): 401-422, 2025 *

  3. Achasova KM, Snytnikova OA, Chanushkina KE, Morozova MV, Tsentalovich YuP, Kozhevnikova EN. Baseline abundance of Akkermansia muciniphila and Bacteroides acidifaciens in a healthy state predicts inflammation associated tumorigenesis in the AOM/DSS mouse model. (doi: 10.1038/s41598-025-96514-5) Sci Rep 15: 12241, 2025

  4. Achasova KM, Kozhevnikova EN. A cohort effect on AOM/DSS colorectal cancer model performance in C57BL/6 mice. (doi: 10.1134/S0022093025020061) J Evol Biochem Phys 61: 438-449, 2025

  5. Arzhanova EL, Makusheva Yu, Pershina EG, Medvedeva SS, Litvinova EA. Changes in the phenotype and metabolism of peritoneal macrophages in Mucin-2 knockout mice and partial restoration of their functions in vitro after L-fucose treatment. (doi: 10.3390/ijms26010013) Int J Mol Sci 26(1): 13, 2025

  6. Andreeva EA, Morozova MV, Saeidi A, Kozhevnikova EN. Evaluation of social odor preference and social communication with the same- and opposite-sex conspecifics in male mice. (doi: 10.1134/S0022093024060292) J Evol Biochem Phys 60(6): 2517-2527, 2024

  7. Popova JV, Bets VD, Omelina ES, Boldyreva LV, Kozhevnikova EN. Adapting mouse genome editing technique from scratch using in utero electroporation. (doi: 10.1134/S0026893324060098) Mol Biol 58(6): 1312-1320, 2024

  8. Klimenko ES, Sukhareva KS, Vlasova YuA, Smolina NA, Fomicheva YuV, Knyazeva A, Muravyev AS, Sorokina MYu, Gavrilova LS, Boldyreva LV, Medvedeva SS, Sejersen T, Kostareva AA. Flnc expression impacts mitochondrial function, autophagy, and calcium handling in C2C12 cells. (doi: 10.1016/j.yexcr.2024.114174) Exp Cell Res 442(1): 114174, 2024

  9. Boldyreva LV, Morozova MV, Pavlov KS, Kozhevnikova EN. Effect of dietary phospholipid on the behavior in C57BL/6J mice. (doi: 10.1134/S0022093024010319) J Evol Biochem Phys 60: 409-419, 2024 *

  10. Morozova MV, Boldyreva LV, Borisova MA, Kozhevnikova EN. Investigating social communication in mice: A two-intruders test approach. (doi: 10.1002/jnr.25365) J Neurosci Res 102(7): e25365, 2024 *

  11. Morozova M, Andrejeva J, Snytnikova O, Boldyreva L, Tsentalovich Yu, Kozhevnikova E.  Phospholipid supplementation inhibits male and female odor discrimination in mice. (doi: 10.3389/fnbeh.2024.1397284) Front Behav Neurosci 18: 1397284, 2024

  12. Saydakova S, Morozova K, Snytnikova O, Morozova M, Boldyreva L, Kiseleva E, Tsentalovich Y, Kozhevnikova E. The effect of dietary phospholipids on the ultrastructure and function of intestinal epithelial cells. (doi: 10.3390/ijms24021788) Int J Mol Sci 24(2): 1788, 2023

  13. Razuvaeva AV, Graziadio L, Palumbo V, Pavlova GA, Popova JV, Pindyurin AV, Bonaccorsi S, Somma MP, Gatti M. The multiple mitotic roles of the ASPM orthologous proteins: Insight into the etiology of ASPM-dependent microcephaly. (doi: 10.3390/cells12060922) Cells 12(6): 922, 2023

  14. Popova J, Bets V, Kozhevnikova E. Perspectives in genome-editing techniques for livestock. (doi: 10.3390/ani13162580) Animals 13(16): 2580, 2023 *

  15. Morozova MV, Borisova MA, Snytnikova OA, Achasova KM, Litvinova EA, Tsentalovich YuP, Kozhevnikova EN. Colitis-associated intestinal microbiota regulates brain glycine and host behavior in mice. (doi: 10.1038/s41598-022-19219-z) Sci Rep 12: 16345, 2022

  16. Popova JV, Pavlova GA, Razuvaeva AV, Yarinich LA, Andreyeva EN, Anders AF, Galimova YA, Renda F, Somma MP, Pindyurin AV, Gatti M. Genetic control of kinetochore-driven microtubule growth in Drosophila mitosis. (doi: 10.3390/cells11142127) Cells 11(14): 2127, 2022

  17. Bets VD, Achasova KM, Borisova MA, Kozhevnikova EN, Litvinova EA. Role of Mucin 2 glycoprotein and L-fucose in interaction of immunity and microbiome within the experimental model of inflammatory bowel disease. (doi: 10.1134/S0006297922040010) Biochemistry (Moscow) 87(4): 301-318, 2022

  18. Omelina ES, Yushkova AA, Motorina DM, Volegov GA, Kozhevnikova EN, Pindyurin AV. Optogenetic and chemical induction systems for regulation of transgene expression in plants: use in basic and applied research. (doi: 10.3390/ijms23031737) Int J Mol Sci 23(3): 1737, 2022

  19. Morozova MV, Kalmykova GV, Akulova NI, Ites YV, Korkina VI, Litvinova EA. Autoclaved diet with inactivated spores of Bacillus spp. decreased reproductive performance of Muc2−/− and Muc2+/− mice. (doi: 10.3390/ani12182399) Animals 12(18): 2399, 2022 *

  20. Boldyreva LV, Morozova MV, Saydakova SS, Kozhevnikova EN. Fat of the gut: epithelial phospholipids in inflammatory bowel diseases. (doi: 10.3390/ijms222111682) Int J Mol Sci 22(21): 11682, 2021 *

  21. Achasova KM, Kozhevnikova EN, Borisova MA, Litvinova EA. Fucose ameliorates Tritrichomonas sp.-associated illness in tntibiotic-treated Muc2−/− mice. (doi: 10.3390/ijms221910699) Int J Mol Sci 22(19): 10699, 2021

  22. Litvinova EA, Bets VD, Feofanova NA, Gvozdeva OV, Achasova KM, Alperina EL, Kozhevnikova EN. Dietary fucose affects macrophage polarization and reproductive performance in mice. (doi: 10.3390/nu13030855) Nutrients 13(3): 855, 2021

  23. Boldyreva LV, Yarinich LA, Kozhevnikova EN, Ivankin AV, Lebedev MO, Pindyurin AV. Fine gene expression regulation by minor sequence variations downstream of the polyadenylation signal. (doi: 10.1007/s11033-021-06160-z) Mol Biol Rep 48: 1539-1547, 2021

  24. Gvozdeva OV, Achasova KM, Litvinova NA, Kozhevnikova EN, Litvinova EA. Female scent activated expression of Arginase1 and inducible NO-Synthetase in lung of BALB/c male mice. (doi: 10.3390/ani11061756) Animals 11(6): 1756, 2021 *

  25. Borisova MA, Achasova KM, Morozova KN, Andreyeva EN, Litvinova EA, Ogienko AA, Morozova MV, Berkaeva MB, Kiseleva E, Kozhevnikova EN. Mucin-2 knockout is a model of intercellular junction defects, mitochondrial damage and ATP depletion in the intestinal epithelium. (doi: 10.1038/s41598-020-78141-4) Sci Rep 10: 21135, 2020

Research Groups

Department of Structure and Function of Chromosomes
Department of Regulation of Genetic Processes