Department of Structure and Function of Chromosomes
Laboratory of Molecular Genetics
Head of the Laboratory
Former research workers:
Gaskov Dmitry
Grishko Ekaterina
Gunbin Konstantin, PhD
Kolesnikov Nikolay, DSc
Lipikhina Yulia
Serdyukova Olga
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Veryaskina YA, Titov SE, Skvortsova NV, Kovynev IB, Antonenko OV, Demakov SA, Demenkov PS, Pospelova TI, Ivanov MK, Zhimulev IF. Multiple myeloma: Genetic and epigenetic biomarkers with clinical potential. (doi: 10.3390/ijms252413404) Int J Mol Sci 25(24): 13404, 2024
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Evtushenko EV, Gatzkaya SS, Stepochkin PI, Vershinin AV. The parental centromere sizes remain unaltered in allopolyploid wheat-rye hybrids.(doi: 10.1159/000541705) Cytogenet Genome Res 164(3-4): 170-179, 2024
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Titov SE, Kozorezova ES, Lukyanov SA, Sergiyko SV, Demenkov PS, Veryaskina YA, Vorobyev SL, Sleptsov IV, Chernikov RA, Timofeeva NI, Barashkova SV, Lushnikova EL, Uspenskaya AA, Zolotoukho AV, Romanova OV, Zhimulev IF. Could SLC26A7 be a promising marker for preoperative diagnosis of high-grade papillary thyroid carcinoma? (doi: 10.3390/diagnostics14232652) Diagnostics 14(23): 2652, 2024
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Veryaskina YA, Titov SE, Kovynev IB, Pospelova TI, Fyodorova SS, Shebunyaeva YY, Demakov SA, Demenkov PS, Zhimulev IF. MicroRNA: A signature for the clinical progression of chronic lymphocytic leukemia. (doi: 10.3390/lymphatics2030013) Lymphatics 2(3): 157-167, 2024
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Lukyanov SA, Titov SE, Kozorezova ES, Demenkov PS, Veryaskina YA, Korotovskii DV, Ilyina TE, Vorobyev SL, Zhivotov VA, Bondarev NS, Sleptsov IV, Sergiyko SV. Prediction of the aggressive clinical course of papillary thyroid carcinoma based on fine needle aspiration biopsy molecular testing. (doi: 10.3390/ijms25137090) Int J Mol Sci 25(13): 7090, 2024
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Koroleva AG, Evtushenko EV, Zaytseva EP, Porfiriev AG, Timoshkin OA, Kirilchik SV. Interstitial telomere sequences in chromosomes of Baikal planarians. (doi: 10.31951/2658-3518-2024-A-1-1) Limnology and Freshwater Biology 1: 1-13, 2024
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Ye WD, Tan LC, Veryaskina YA, Han PZ, Yu PC, Shi X, Liu WL, Kai ZT, Lin RJ, Huang LS, Semenov A, Zhimulev IF, Ji QH, Qu N, Titov SE, Wang YL. Synchronous papillary and follicular thyroid carcinomas: the first retrospective cohort study and literature review. (doi: 10.21037/tcr-23) Transl Cancer Res 13(4): 1924-1935, 2024
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Lukyanov SA, Sergiyko SV, Titov SE, Beltsevich DG, Veryaskina YA, Vanushko VE, Urusova LS, Mikheenkov AA, Kozorezova ES, Vorobyov SL, Sleptsov IV. New opportunities for preoperative diagnosis of medullary thyroid carcinoma. (doi: 10.3390/biomedicines11051473) Biomedicines 11(5): 1473, 2023
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Ivanov MK, Brenner EV, Hodkevich AA, Dzyubenko VV, Krasilnikov SE, Mansurova AS, Vakhturova IE, Agletdinov EF, Shumeikina AO, Chernyshova AL, Titov SE. Cervicovaginal-microbiome analysis by 16S sequencing and Real-Time PCR in patients from Novosibirsk (Russia) with cervical lesions and several years after cancer treatment. (doi: 10.3390/diagnostics13010140) Diagnostics 13(1): 140, 2023
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Veryaskina YA, Titov SE, Kovynev IB, Pospelova TI, Fyodorova SS, Shebunyaeva YY, Sumenkova DV, Zhimulev IF. MicroRNA expression profile in bone marrow and lymph nodes in B-cell lymphomas. (doi: 10.3390/ijms242015082) Int J Mol Sci 24(20): 15082, 2023
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Vershinin AV, Elisafenko EA, Evtushenko EV. Genetic redundancy in rye shows in a variety of ways. (doi: 10.3390/plants12020282) Plants 12(2): 282, 2023
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Stupak EV, Veryasikina YA, Titov SE, Askandaryan AS, Hiana JC, Zhimulyov IF, Stupak VV. MicroRNAs in the diagnosis of malignancy of supratentorial brain gliomas and prognosis of disease progression. (doi: 10.7759/cureus.35906) Cureus 15(3): e35906, 2023
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Mikhailova AG, ... Gunbin K, Popadin K. A mitochondria-specific mutational signature of aging: increased rate of A > G substitutions on the heavy strand (doi: 10.1093/nar/gkac779) Nucleic Acids Res 50(18): 10264-10277, 2022
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Kazachkov EL, Semenov YuA, Veryaskina YuA, Kazachkova EA, Chizhovskaya AV. The expression profi le of a number of miRNAs in the placenta in timely and premature birth. (doi: 10.31549/2542-1174-2022-6-1-22-37) Journal of Siberian Medical Sciences 6(1): 22-37, 2022
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Veryaskina YA, Titov SE, Zhimulev IF. Reference genes for qPCR-based miRNA expression profiling in 14 human tissues. (doi: 10.1159/000524283) Med Princ Pract 31: 322-332, 2022
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Ryabinin VA, Akimov IA, Sinyakov AN, Pichko NP, Ivanov MK. Hepatitis C virus RF1_2k/1b chimeras and a “Many probes/one spot” approach to their identification. (doi: 10.1134/S1068162022010095) Rus J Bioorg Chem 48(1): 173-177, 2022
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Veryaskina YuA, Titov SE, Ivanov MK, Ruzankin PS, Tarasenko AS, Shevchenko SP, Kovynev IB, Stupak EV, Pospelova TI, Zhimulev IF. Selection of reference genes for quantitative analysis of microRNA expression in three different types of cancer. (doi: 10.1371/journal.pone.0254304) PLoS ONE 17(2): e0254304, 2022
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Elisafenko EA, Evtushenko EV, Vershinin AV. The origin and evolution of a two-component system of paralogous genes encoding the centromeric histone CENH3 in cereals. (doi: 10.1186/s12870-021-03264-3) BMC Plant Biol 21: 541, 2021
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Vershinin AV, Lux T, Gundlach H, Elisafenko EA, Keilwagen J, Mayer KFX, Spannagl M. The gene and repetitive element landscape of the rye genome. In: "The Rye Genome" (Rabanus-Wallace MT, Stein N, Eds), Springer, pp 117-133, 2021 (doi: 10.1007%2F978-3-030-83383-1_8)
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Evtushenko EV, Elisafenko EA, Gatzkaya SS, Schubert V, Houben A, Vershinin AV. Expression of two rye CENH3 variants and their loading into centromeres. (doi: 10.3390/plants10102043) Plants 10(10): 2043, 2021
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Ivanov MK, Titov SE, Dzyubenko VV, Glushkov SA, Krasilnikov SE, Mansurova AS, Malek AV, Berlev IV, Prisyazhnaya TS, Kuleshova SV, Hodkevich AA, Lancuhaj YA, Dimitriadi TA, Agletdinov EF. Detection of cervical lesions and cancer in air-dried cytologic smears by combined analysis of mRNA and miRNA expression levels. (doi: 10.1016/j.jmoldx.2021.01.016) J Mol Diagn 23(5): 541-554, 2021
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Titov SE, Poloz TL, Veryaskina YA, Anishchenko VV. Cytological and molecular diagnosis of Hürthle cell thyroid tumors: Analysis of three cases. (doi: 10.3892/mco.2021.2311) Mol Clin Oncol 15(1): 149, 2021
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Konnikova MR, Cherkasova OP, Nazarov MM, Vrazhnov DA, Kistenev YV, Titov SE, Kopeikina EV, Shevchenko SP, Shkurinov AP. Malignant and benign thyroid nodule differentiation through the analysis of blood plasma with terahertz spectroscopy. (doi: 10.1364/BOE.412715) Biomed Opt Express 12(2): 1020-1035, 2021
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Veryaskina YA, Titov SE, Kovynev IB, Fedorova SS, Pospelova TI, Zhimulev IF. MicroRNAs in the myelodysplastic syndrome. (doi: 10.32607/actanaturae.11209) Acta Naturae 13(2): 4-15, 2021
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Titov SE, Kozorezova ES, Demenkov PS, Veryaskina YA, Kuznetsova IV, Vorobyev SL, Chernikov RA, Sleptsov IV, Timofeeva NI, Ivanov MK. Preoperative typing of thyroid and parathyroid tumors with a combined molecular classifier. (doi: 10.3390/cancers13020237) Cancers 13(2): 237, 2021
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Kovynev IB, Titov SE, Ruzankin PS, Agakishiev MM, Veryaskina YA, Nedel’ko VM, Pospelova TI, Zhimulev IF. Profiling 25 bone marrow microRNAs in acute leukemias and secondary nonleukemic hematopoietic conditions. (doi: 10.3390/biomedicines8120607) Biomedicines 8(12): 607, 2020
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Ellis THN, Vershinin AV. Retrotransposons and the evolution of genome size in Pisum. (doi: 10.3390/biotech9040024) BioTech 9(4): 24, 2020
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Titov S, Demenkov PS, Lukyanov SA, Sergiyko SV, Katanyan GA, Veryaskina YA, Ivanov MK. Preoperative detection of malignancy in fine-needle aspiration cytology (FNAC) smears with indeterminate cytology (Bethesda III, IV) by a combined molecular classifier. (doi: 10.1136/jclinpath-2020-206445) J Clin Pathol 73(11): 722-727, 2020
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Koroleva AG, Evtushenko EV, Vershinin AV, Zaytseva EP, Timoshkin OA, Kirilchik SV. Age dynamics of telomere length in endemic Baikal planarians (doi: 10.1134/S002689332004007X) Mol Biol 54(4): 553-562, 2020
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Veryaskina YuA, Titov SE, Kovynev IB, Pospelova TI, Zhimulev IF. The miRNA profile in non-Hodgkin’s lymphoma patients with secondary myelodysplasia. (doi: 10.3390/cells9102318) Cells 9(10): 2318, 2020
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Veryaskina YuA, Titov SE, Kovynev IB, Pospelova TI, Zhimulev IF. Prognostic markers of myelodysplastic syndromes. (doi: 10.3390/medicina56080376) Medicina 56(8): 376, 2020
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Veryaskina YuA, Titov SE, Kometova VV, Rodionov VV, Zhimulev IF. Intratumoral heterogeneity of expression of 16 miRNA in luminal cancer of the mammary gland. (doi: 10.3390/ncrna6020016) Non-Coding RNA 6(2): 16, 2020
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Evtushenko EV, Lipikhina YuA, Stepochkin PI, Vershinin AV. Cytogenetic and molecular characteristics of rye genome in octoploid triticale (× Triticosecale Wittmack). (doi: 10.3897/CompCytogen.v13i4.39576) Comp Cytogenet 13(4): 423-434, 2019
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Titov SE, Ivanov MK, Demenkov PS, Katanyan GA, Kozorezova ES, Malek AV, Veryaskina YuA, Zhimulev IF. Combined quantitation of HMGA2 mRNA, microRNAs, and mitochondrial-DNA content enables the identification and typing of thyroid tumors in fine-needle aspiration smears. (doi: 10.1186/s12885-019-6154-7) BMC Cancer 19: 1010, 2019
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Kolesnikov NN, Veryaskina YuA, Titov SE, Rodionov VV, Gening TP, Abakumova TV, Kometova VV, Torosyan MKh, Zhimulev IF. Expression of micrornas in molecular genetic breast cancer subtypes. (doi: 10.1016/j.ctarc.2016.08.006) Cancer Treat Res Commun 20: 100026, 2019
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Terletsky AV, Akhmerova LG, Evtushenko EV. Blood parasite infection causing inflammatory reactions and benign formations in human thyroid gland. (doi: 10.15789/2220-7619-2019-1-155-161) Rus J Infection Immunity 9(1): 155-161, 2019
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Gatzkaya SS, Evtushenko EV. Patterns of nucleotide diversity for different domains of centromeric histone H3 (CENH3) gene in Secale L. (doi: 10.18699/VJ19.472) Vavilov J Genetics Breeding 23(2): 135-139, 2019
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Serdyukova OS, Titov SE, Malakhina ES, Rymar OD. MicroRNAs – promising molecular markers for detecting cancer in thyroid nodules. (doi: 10.14341/ket9774) Clinical and experimental thyroidology 14(3): 140-148, 2018 (Abstract in English)
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Lipikhina YuA, Evtushenko EV, Lyusikov OM, Gordei IS, Gordei IA, Vershinin AV. Dynamics of the centromeric histone CENH3 structure in rye-wheat amphidiploids (Secalotriticum). (doi: 10.1155/2018/2097845) BioMed Res Int 2018: 2097845, 2018
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Ovsyannikova AK, Rymar OD, Ivanoshchuk DE, Mikhailova SV, Shakhtshneider EV, Orlov PS, Malakhina ES, Voevoda MI. A case of maturity onset diabetes of the young (MODY3) in a family with a novel HNF1A gene mutation in five generations. (doi: 10.1007/s13300-017-0350-8) Diabetes Ther 9(1): 413-420, 2018
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Ivanov MK, Titov SE, Glushkov SA, Dzyubenko VV, Malek AV, Arkhangelskaya PA, Samsonov RB, Mikhetko AA, Bakhidze EV, Berlev IV, Kolesnikov NN. Detection of high-grade neoplasia in air-dried cervical PAP smears by a microRNA-based classifier. (doi: 10.3892/or.2018.6214) Oncology Rep 39: 1099-1111, 2018
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Lipikhina YA, Evtushenko EV, Elisafenko EA, Vershinin AV. Chromosomal assignment of centromere-specific histone CENH3 genes in rye (Secale cereale L.) and their phylogeny. (doi: 10.3897/CompCytogen.v11i4.19953) Comp Cytogenet 11(4): 821-832, 2017
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Evtushenko EV, Elisafenko EA, Gatzkaya SS, Lipikhina YA, Houben A, Vershinin AV. Conserved molecular structure of the centromeric histone CENH3 in Secale and its phylogenetic relationships. (doi: 10.1038/s41598-017-17932-8) Sci Reports 7: 17628, 2017
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Stolyar M, Klimova O, Ivanov M, Gorbenko A, Titov S, Olkhovskiy I. JAK2 haplotype 46/1 (GGCC) has no effect on the primary risk of JAK2 V617F mutation, but it strongly potentiates the progression of grown allele burden in myeloproliferative neoplasms. Haematologica 102(s2): 539, 2017
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Malek A, Sleptsov I, Cheburkin Y, Samsonov R, Kolesnikov N. miRNA as potential tool for thyroid cancer diagnostics and follow up: practical considerations. JSM Thyroid Disord Manag 2(1): 1007, 2017
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Boldyreva LV, Goncharov FP, Demakova OV, Zykova TYu, Levitsky VG, Kolesnikov NN, Pindyurin AV, Semeshin VF, Zhimulev IF. Protein and genetic composition of four chromatin types in Drosophila melanogaster cell lines. (doi: 10.2174/1389202917666160512164913) Curr Genomics, 18(2): 214-226, 2017
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Stupak EV, Veryaskina YuA, Titov SE, Achmerova LG, Stupak VV, Ivanov MK, Zhimulev IF, Kolesnikov NN. MicroRNA profiling in the malignant progression of gliomas. AIP Conf Proc 1760, 020065, doi: 10.1063/1.4960284, 2016
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Evtushenko EV, Levitsky VG, Elisafenko EA, Gunbin KV, Belousov AI, Šafář J, Doležel J, Vershinin AV. The molecular mechanisms of heterochromatin expansion in rye chromosomes. Cytogenet Genome Res 148: 91, 2016
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Titov SE, Demenkov PS, Ivanov MK, Malakhina ES, Poloz TL, Tsivlikova EV, Ganzha MS, Shevchenko SP, Gulyaeva LF, Kolesnikov NN. Selection and validation of miRNAs as normalizers for profiling expression of microRNAs isolated from thyroid fine needle aspiration smears. (doi: 10.3892/or.2016.5113) Oncology Rep 36: 2501-2510, 2016
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Samsonov R, Burdakov V, Shtam T, Radzhabovа Z, Vasilyev D, Tsyrlina E, Titov S, Ivanov M, Berstein L, Filatov M, Kolesnikov N, Gil-Henn H, Malek A. Plasma exosomal miR-21 and miR-181a differentiates follicular from papillary thyroid cancer. (doi: 10.1007/s13277-016-5065-3) Tumor Biol 37: 12011-12021, 2016
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Evtushenko EV, Levitsky VG, Elisafenko EA, Gunbin KV, Belousov AI, Šafář J, Doležel J, Vershinin AV. The expansion of heterochromatin blocks in rye reflects the co-amplification of tandem repeats and adjacent transposable elements. (doi: 10.1186/s12864-016-2667-5) BMC Genomics 17(1): 337, 2016
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Titov SE, Ivanov MK, Karpinskaya EV, Tsivlikova EV, Shevchenko SP, Veryaskina YA, Akhmerova LG, Poloz TL, Klimova OA, Gulyaeva LF, Zhimulev IF, Kolesnikov NN. miRNA profiling, detection of BRAF V600E mutation and RET-PTC1 translocation in patients from Novosibirsk oblast (Russia) with different types of thyroid tumors. (doi: 10.1186/s12885-016-2240-2) BMC Cancer 16: 201, 2016
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Shevchenko S, Mostovich L, Kolesnikov N, Gulyaeva L. Molecular biomarkers in preoperative diagnosis of thyroid cancer. Eur J Cancer Suppl 13(1): 52, 2015
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Evtushenko EV. Evolutionary dynamics of the centomeric histone CENH3 in the Triticeae tribe. International Conference “Chromosome – 2018”, 20-24 August 2018, Novosibirsk, Russia
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Vershinin A. The molecular mechanisms of the heterochromatin expansion in the rye chromosomes. 21st International Chromosome Conference. July 10-13, 2016, Foz do Iguaçu, Brazil
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Vershinin AV. Intensive recombinations have led to tandem repeat expansion and enlargement of rye subtelomeric heterochromatin. The 19th International Chromosome Conference. 2-6 September 2013, Bologna, Italy
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Vershinin AV. Genomics of rye subtelomeric heterochromatin. 11th Gatersleben Research Conference "Chromosome biology, genome evolution, and speciation" 23-25 April 2012, Gatersleben, Germany
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Vershinin AV. The genomics of the most abundant tandem repeat DNA families in the rye heterochromatin. Annual Main Meeting of the Society for Experimental Biology. Chromosome Organization and Cytogenomics, 30 June - 3 July 2010, Prague, Czech Republic
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Kolesnikov NN. X-chromosome inactivation, mobile elements and ncRNA genes. 6th International Conference on Bioinformatics of Genome Regulation and Structure, 22-28 June 2008, Novosibirsk, Russia
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Kolesnikov NN. Evolution of the structure of the XIST locus in mammals. 5th International Conference on Bioinformatics of Genome Regulation and Structure, 16-22 July 2006, Novosibirsk, Russia
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Leibniz-Institut für Pflanzengenetik und Kulturpflanzenforschung, Gatersleben, Germany
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Institute of Experimental Botany, Olomouc, Czech Republic
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Institute of Genetics and Cytology, Minsk, Belarus
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John Innes Centre, Norwich, UK